Relia Tech：抗原亲和纯化LYVE1抗体

发布者：艾美捷科技发布时间：2022-07-28

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LYVE1抗体

LYVE-1(Lymphatic Vessel Endothelial Receptor-1)，淋巴管内皮受体1 是白细胞受体CD44的近亲，LYVE-1的推断氨基酸序列显示，它是一个具有322个残基的I型整体膜多肽，与CD44的HA受体有41%的相似性，其胞外结构域为212个残基，包含一个Link模块，即Link蛋白超家族的原型HA结合域。与CD44一样，LYVE-1分子同时结合可溶性和固定化的HA。然而，与CD44不同的是，LYVE-1分子在淋巴管壁的管腔面上与HA共定位，而在血管中则完全没有。LYVE1是淋巴管内皮细胞透明质酸（HA）的主要受体，是区分血管和淋巴管的常用标志物。

LYVE1抗体

一般的抗体生产公司通常会使用Protein A/G进行亲和纯化抗体，这样生产的抗体亲和力和纯度很难达到理想的高度。作为专业的生命科学医药原料和解决方案供应商，艾美捷科技为您推荐德国，Relia Tech荣誉出品：抗原亲和纯化的，LYVE1抗体，Nature, Cell都在用！

LYVE1抗体

产品名称	Rabbit Anti-Human Lyve-1	Rabbit Anti-Mouse Lyve-1
特异性	人（不与Mouse交叉反应）	鼠
货号	102-PA50AG	103-PA50AG
发表文献	31篇	76篇
说明书	点击下载	点击下载
应用类型	WB, IHC (P, F), IF，FC	WB, IHC (C), IF, FC
免疫原	重组人sLYVE-1（Ser24-Gly232）	重组小鼠sLYVE-1（Ala24-Gly228）
纯化方式	抗原亲和纯化法
产品形式	50ug冻干粉（仅含PBS盐）；建议加无菌水重溶至0.1 - 1 mg/ml.
保存条件	冻干粉抗体在 -20℃保存 2 年。无菌复溶后，抗体可在 2-8℃下稳定长达 6 个月。冷冻等分试样在 -20℃下可稳定保存至少 6个月。对于冷冻等分试样，建议添加载体蛋白或 50% 甘油。

* 以上产品仅限科研使用，不得用于人体或医疗。

人Lyve-1抗体（102-PA50AG）文章结果共赏：

人Lyve-1抗体

来自《Nature》Rantakari, Pia et al. "Fetal liver endothelium regulates the seeding of tissue-resident macrophages". Nature vol. 538,7625 (2016): 392-396.

小鼠Lyve-1抗体（103-PA50AG）文章结果共赏：

小鼠Lyve-1抗体

来自《Cell》 Okabe, Keisuke, et al. "Neurons limit angiogenesis by titrating VEGF in retina." Cell 159.3 (2014): 584-596.

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PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease. Winkler F. et al., Sci Rep. 2018 Dec 4;8(1):17582.
Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response. Y. Kimizuka et al., J Immunol. 2018 Dec 15;201(12):3587-3603.
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Endothelial cell fitness dictates the source of regenerating liver vasculature. Singhal M. et al., J Exp Med. 2018 Oct 1;215(10):2497-2508.
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. Pekkonen P. et al., Elife. 2018 May 1;7. pii: e32490.
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms. Y. Zhang et al., Nat Commun. 2018; 9: 1296.
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. M. Frye et al., Nat Commun. 2018 Apr 17;9(1):1511.
PROX1 is a transcriptional regulator of MMP14. Gramolelli S. et al., Sci Rep. 2018 Jun 22;8(1):9531.
T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors. T. Manzo et al., Cancer Res January 31 2017 77 (3) 658-671
Placental growth factor-1 attenuates vascular endothelial growth factor-A-dependent tumor angiogenesis during beta cell carcinogenesis. T. Schomber et al., Cancer Res. 2007 Nov 15;67(22):10840-8
Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. A. T. Boutin et al., Genes Dev. 2017 Feb 15; 31(4): 370–382.
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair. O. Barreiro et al., eLife. 2016; 5: e15251.
Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. P.-S. Koch et al., Blood. 2017 Jan 26; 129(4): 415–419.
The lymphatic vascular system of the mouse head. M. Lohrberg and J. Wilting, Cell Tissue Res. 2016; 366(3): 667–677.
Phenotypic transformation of intimal and adventitial lymphatics in atherosclerosis: a regulatory role for soluble VEGF receptor 2. M. Taher et al., FASEB J. 2016 Jul; 30(7): 2490–2499.
EPHB4 kinase–inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. S. Martin-Almedina et al., J Clin Invest. 2016 Aug 1; 126(8): 3080–3088.
Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic. I. Iftakhar-E-Khuda et al., Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): 10643–10648.
Medicinal facilities to B16F10 melanoma cells for distant metastasis control with a supramolecular complex by DEAE-dextran-MMA copolymer/paclitaxel. Eshita Y. et al., Drug Deliv Transl Res. 2015 Feb;5(1):38-50.
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Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties. M. Augsten et al., Cancer Res. 2014 Jun 1;74(11):2999-3010
The effect of podoplanin inhibition on lymphangiogenesis under pathological conditions. Maruyama Y et al., Invest Ophthalmol Vis Sci. 2014 Jul 1;55(8):4813-22.
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Apelin promotes lymphangiogenesis and lymph node metastasis. J. Berta et al., Oncotarget. 2014 Jun; 5(12): 4426–4437.
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Absence of lymphatic vessels in term placenta. J. Becker et al., BMC Pregnancy Childbirth. 2020; 20: 380.
Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices. L. Knezevic et al., Front Bioeng Biotechnol. 2017; 5: 25.
TGFβ counteracts LYVE-1-mediated induction of lymphangiogenesis by small hyaluronan oligosaccharides. Bauer J. et al., J Mol Med (Berl). 2018 Feb;96(2):199-209.
ELM: A New, Simple, and Economic Assay to Measure Motility of Lymphatic Endothelial Cells. F. Torri et al., Res Biol. 2017 Mar 1; 15(1): 39–44.
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Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors. V. Hasselhof et al., PLoS One. 2016; 11(10): e0164964.
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TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis. M-F Pang et al., Oncogene. 2016 Feb 11; 35(6): 748–760.
Generation of pure lymphatic endothelial cells from human pluripotent stem cells and their therapeutic effects on wound repair. Shin-Jeong Lee et al., Sci Rep. 2015; 5: 11019.
Adhesion of Pancreatic Cancer Cells in a Liver-Microvasculature Mimicking Coculture Correlates with Their Propensity to Form Liver-Specific Metastasis In Vivo. M. Mahfuz Chowdhury et al., Biomed Res Int. 2014; 2014: 241571.
Arterial wall lymphangiogenesis is increased in the human iliac atherosclerotic arteries: involvement of CCR7 receptor. Grzegorek I. et al., Lymphat Res Biol. 2014 Dec;12(4):222-31.
Lymphangiogenesis and angiogenesis during human fetal pancreas development. M. S. Roost et al., Vasc Cell. 2014; 6: 22.
Lack of Lymphatics and Lymph Node–Mediated Immunity in Choroidal Neovascularization. S. Nakao et al., Invest Ophthalmol Vis Sci. 2013 Jun; 54(6): 3830–3836.
Plasticity of Blood- and Lymphatic Endothelial Cells and Marker Identification. J. Keuschnigg et al., PLoS One. 2013; 8(9): e74293.
High density of peritumoral lymphatic vessels measured by D2-40/podoplanin and LYVE-1 expression in gastric cancer patients: an excellent prognostic indicator or a false friend? J. Rudno-Rudzinska et al., Gastric Cancer. 2013; 16(4): 513–520.
Increased lymphatic vessel density and lymphangiogenesis in inflammatory bowel disease. Rahier JF et al., Aliment Pharmacol Ther. 2011 Sep;34(5):533-43.
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. J. Kang et al., Blood. 2010 Jul 8; 116(1): 140–150.
Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Smith NR et al., Clin Cancer Res. 2010 Jul 15;16(14):3548-61.
Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. G. Jurisic et al., Exp Cell Res. 2010 Oct 15; 316(17): 2982–2992.
Exercise-induced decline in the density of LYVE-1-positive lymphatic vessels in human skeletal muscle. Gehlert S. et al., Lymphat Res Biol. 2010 Sep;8(3):165-73.
Regeneration of autotransplanted avascular lymph nodes in the rat is improved by platelet-rich plasma. Hadamitzky C et al., J Vasc Res. 2009;46(5):389-96.
Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells. S. Christian et al., Am J Pathol. 2008 Feb; 172(2): 486–494.
Altered regulation of Prox1-gene-expression in liver tumors. J. Dudas etal., BMC Cancer. 2008; 8: 92.
Chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes. Kawai Y. et al., Cancer Sci. 2009 Mar;100(3):419-28.
The lymphatic ring assay: a 3D-culture model of lymphangiogenesis. F. Bruyère et al., Protocol Exchange (2008)
Jugular lymphatic maldevelopment in Turner syndrome and trisomy 21: different anomalies leading to nuchal edema. Bekker MN et al., Reprod Sci. 2008 Apr;15(3):295-304.