Anacardic Acid is a pentadecane aliphatic chain containing hydroxylcarboxylic acid. The acid is an effective inhibitor of the activities of p300 and p300/CBP associated factor histone acetyltransferase. Additionally， it has been shown to potently inhibit HAT-dependent transcription and SUMOylation， as well as decrease expression of NF-κB regulated gene products including， invasion， proliferation， inflammation， and cell survival. Research suggests that anacardic acid may be a potent activator of ARK-1 （Aurora kinase A） mediated phosphorylation of histone H3， and a novel activator of Aurora kinase. Anacardic Acid has demonstrated bactericidal activity against methicillin-resistant Staphylococcus aureus （MRSA）.
