英文名字 Human Endothelin-1
中文名称 【EDN1】人内皮素1
供应商 ProSpec
产品货号 HOR-307
产品报价 ¥规格或产品已更新
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产品新闻
背景资料 EDN1 is a powerful mitogen mediator of smooth muscle tone, and inflammatory regulator that is involved in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. Endothelin-2 and Endothelin-3 vary from Endothelin-1 by two and six amino acids, respectively, and share homology, particularly at the carboxy terminus with sarafotoxins a-e. The lung has the largest levels of EDN1 secreted by endothelium, smooth muscle, airway epithelium, and a diversity of other cells. ET-1 also circulates in the plasma. Endothelin-1 along with endothelin-2, & endothelin-3 (ET-3) consist of the endothelin family of 21 amino acid peptides manufactured in a variety of cells and tissues, particularly endothelial and epithelial lineages. These endothelins are derivatives from three genes. The endothelins are normally connected with hypertension, though they regulate a diversity of other effects through two G-protein coupled receptors, ET-A and ET-B. The endothelins are derivatives from a precursor peptides using cleavage by metalloproteases for instance endothelin-converting enzymes.
序列 Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp.
来源宿主
溶解建议 提供的人内皮素1产品为白色无菌冻干粉末,冻干粉里不含有其它添加剂.推荐使用无菌的18MΩ的超纯水来溶解,浓度不低于100ug/ml,便于后续稀释.
保存建议 Lyophilized EDN1 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution EDN1 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
产品说明书
其他 以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产.其独有细菌和哺乳动物表达和蛋白折叠技术使其成为国际一流科研级蛋白供应商.ProSpec-Tany是世界上能提供蛋白种类最多公司之一.领先生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司.作为多家知名品牌代理,艾美捷与ProSpec一起为研究者们提供最好、最新细胞生物学研究工具而不断扩大产品及服务质量.

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