Cyclosporin A is a noncytotoxic, natural, 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function, which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless, Cyclosporin A -induced nephrotoxicity remains an important clinical problem, and oxidative stress has been implicated as a potential responsible mechanism.
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Beauveria Nlyea.中提取纯化
溶解建议
Sterile Filtered White lyophilized (freeze-dried) powder. The Cyclosporin-A was lyophilized from a concentrated (1mg/ml) solution with no additives. It is recommended to reconstitute the lyophilized Cyclosporin A in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized Cyclosporin A although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution Cyclosporin A should be stored at 4℃ between 2-7 days and for future use below -18℃.
Please prevent freeze-thaw cycles.