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中文名称

【GPHA2】重组人糖蛋白激素a

英文名字
Recombinant Human Thyrostimulin Alpha
供应商
ProSpec
产品货号
HOR-258
产品报价
¥询价/10ug   ¥1mg   ¥2ug
产品说明书
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产品新闻
背景资料
Human thyrostimulin ranks among the glycoprotein hormone family. These hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. The alpha-subunit combines with four distinct beta-subunits giving rise to four biologically active hormones in human: FSH, LH, TSH, and CG. FSH, LH, and TSH, mainly expressed in the anterior pituitary, are essential for coordinated endocrine regulation in the hypothalamus- pituitary axis and show to activate specific G protein–coupled receptors in the thyroid (TSH receptor) and gonads (LH and FSH receptors), respectively.
The heterodimeric glycoprotein hormones have only been identified in vertebrates and are highly conserved in organisms from primitive rayfin fish (Chondrostei) to human in both primary sequences and functional characteristics.
Corticotroph-derived glycoprotein hormone (CGH), also referred to as thyrostimulin, is a noncovalent heterodimer of glycoprotein hormone alpha 2 (GPHA2) and glycoprotein hormone beta 5 (GPHB5).
Recombinant A2/B5 heterodimeric glycoproteins activates human TSH receptors, but not LH and FSH receptors, and shows high affinity to TSH receptors in a radioligand receptor assay. The heterodimer also stimulates cAMP production and thymidine incorporation by cultured thyroid cells and increases serum thyroxine levels in TSH-suppressed rats in vivo. This new heterodimeric glycoprotein hormone was named as thyrostimulin based on its thyroid-stimulating activity. The expression of thyrostimulin in the anterior pituitary known to express TSH receptors suggested a paracrine mechanism.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的重组人糖蛋白激素a产品为白色无菌冻干粉末,推荐使用0.1M 乙酸(pH 4)配制工作液浓度到0.5 mg/ml确保冻干粉完全溶解.由于浓度越高,该蛋白溶解能力越低;如果需要用于更高pH的体系,建议使用相关溶液进一步稀释到10ug/ml浓度.推荐使用去离子水来配制工作液,浓度大约为0.5 mg/ml,确保冻干粉完全溶解. 产品不是无菌的!在细胞培养前请注意过滤灭菌.
保存建议
Lyophilized Thyrostimulin although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution GPHA2 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
其他
ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司,具有20多年的生产经验,专注于蛋白(重组及合成)生产研发。我们的核心产品包括:干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。
注意
该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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