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Recombinant Human Glucagon
中文名称 【Glucagon】重组人胰高血糖素
供应商 ProSpec 产品货号 HOR-237
产品报价 ¥800/100ug   ¥2080/0.5mg   ¥4025/1mg

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背景资料 Glucagon is an important hormone involved in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells (?-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Glucagon is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into glucose and release it into the bloodstream. The action of glucagon is thus opposite to that of insulin, which instructs the body’s cells to take in glucose from the blood in times of satiation.
Glucagon is beneficial for the culture of some cell types. It has been used in some biochemical regulation studies of glycogenolysis in hepatocytes. It has been also been found to induce DNA replication in primary cultures of adult rat hepatocytes when used in combinations with EGF and Insulin. Glucagon increases the blood glucose concentration by promoting rapid breakdown of liver glycogen, and also acts to relax smooth muscle such as the gastrointestinal tract.
产品描述 Glucagon Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3483 Dalton. The Glucagon is purified by proprietary chromatographic techniques.
来源宿主 大肠杆菌中重组表达
序列
The sequence of the first five N-terminal amino acids was determined and was found to be His-Ser-Gln-Gly-Thr.
溶解建议 提供的重组人胰高血糖素产品为白色无菌冻干粉末.推荐使用无菌的18MΩ的超纯水来溶解,浓度不低于100ug/ml,便于后续稀释.
保存建议 Lyophilized Glucagon although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution Glucagon should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
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