英文名字 Recombinant Human Glucagon Like Peptide-1 (7-36)
中文名称 【GLP 1】重组人胰高血糖素样肽1(7-36)
供应商 ProSpec
产品货号 HOR-236
产品报价 ¥800/10ug   ¥2080/50ug   ¥21735/1mg
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产品新闻
背景资料 Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a guthormone. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2.
GLP-1 secretion by L cells is dependent on the presence of nutrients in the lumen of the small intestine. The secretagogues (agents that causes or stimulates secretion) of this hormone include major nutrients like carbohydrate, proteinand lipid. Once in the circulation, GLP-1 has a half life of less than 2 minutes, due to rapid degradation by the enzyme dipeptidyl peptidase-4.
GLP-1 possesses several physiological properties that make it a subject of intensive investigation as a potential treatment of diabetes mellitus. The known physiological functions of GLP-1 include: Increases insulin secretion from the pancreas in a glucose-dependent manner, decreases glucagon secretion from the pancreas, increases beta cells mass and insulin gene expression, inhibits acid secretion and gastric emptying in the stomach, decreases food intake by increasing satiety.
序列 The sequence of the first five N-terminal amino acids was determined and was found to be His-Ala-Glu-Gly-Thr.
来源宿主 大肠杆菌中重组表达
溶解建议 提供的重组人胰高血糖素样肽1(7-36)产品为白色无菌冻干粉末.推荐使用无菌的18MΩ的超纯水来溶解,浓度不低于100ug/ml,便于后续稀释.
保存建议 Lyophilized Glucagon Like Peptide-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution GLP-1 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
产品说明书
其他 以色列ProSpec-Tany公司专注于细菌来源重组蛋白质生产.其独有细菌和哺乳动物表达和蛋白折叠技术使其成为国际一流科研级蛋白供应商.ProSpec-Tany是世界上能提供蛋白种类最多公司之一.领先生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司.作为多家知名品牌代理,艾美捷与ProSpec一起为研究者们提供最好、最新细胞生物学研究工具而不断扩大产品及服务质量.

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