MTPN is an ankyrin repeat protein,that stimulates protein synthesis and cardiomyocyte growth to commence cardiac hypertrophy by activating the NF-kappaB signaling cascade. Myotrophin participates in cerebellar morphogenesis and takes part in differentiation of cerebellar neurons,particularly of granule cells. High levels of MTPN are expressed in human dilated cardiomyopathic and ischemic hearts.