Recombinant Human Sonic Hedgehog is part of a small group of secreted proteins that are vital for development in both vertebrates and invertebrates. 3 mammalian hedgehog genes (sonic,desert,Indian) share about 60% homology. The Human Sonic Hedgehog is 99% homologous to the mouse gene. Sonic HedgeHog is a protein that is vital in guding the early embryo. It has been associated as the major inductive signal in patterning of the ventral neural tube,the anterior-posterior limb axis,and the ventral somites. Sonic HedgeHog binds to the patched receptor,which functions in association with smoothened,to activate the transcription of target genes. In the absence of sonic HedgeHog,patched receptor represses the constitutive signaling activity of smoothened. Sonic HedgeHog also regulates another factor,the gli oncogene. Sonic HedgeHog intercellular signal is essential for a various patterning events during development: signal produced by the notochord that induces ventral cell fate in the
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大肠杆菌中重组表达
溶解建议
提供的人音猬因子,His标签(SHH,His)产品为过滤灭菌的无色溶液;其中人音猬因子,His标签(SHH,His)产品溶解于20mM Tris HCL(pH 8),0.1M NaCl,10%甘油溶液中.