Prolactin is a lactogenic hormone secreted by the adenohypophysis .Besides its major action on lactation,in some species prolactin exerts effects on reproduction,maternal behavior,fat metabolism,immunomodulation and osmoregulation.Prolactin has been shown also to have cytokine-like activities and to have important immunoregulatory activities. It contributes to the development of lymphoid tissues and the maintenance of physiological immune function and also modulates a variety of T-cell immune responses. Prolactin has been reported to activate cellular proliferation in nonreproductive tissue,such as liver,spleen,and thymus. It induces significant proliferation in aortic smooth muscle cells and also enhances proliferation of these cells induced by PDGF . Prolactin also appears to be directly mitogenic for pancreatic beta cells. Prolactin is also mitogenic for cultured astrocytes.
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大肠杆菌中重组表达
溶解建议
提供的绵羊催乳素受体拮抗剂突变体(oPrl A Mutant)产品为过滤灭菌的白色冻干粉末;该冻干粉末是从含1mg/ml绵羊催乳素受体拮抗剂突变体(oPrl A Mutant)的0.02%-0.03% NaHCO3溶液中冻干产生的.我们建议加无菌的18MΩ-cm水以配制工作储存液到不低于100ug/ml,后继实验过程中可根据实验要求进一步稀释.
保存建议
绵羊催乳素受体拮抗剂突变体(oPrl A Mutant)在室温可保存3周,或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天;如果想延长保存时间,建议分装(加载体蛋白如0.1% HSA或 BSA)后置于-18℃冻存.请避免反复冻融.