DHH is part of the Hedgehog family which encodes signaling molecules that are involved in regulating morphogenesis. DHH protein is a precursor that is autocatalytically cleaved,the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. Additionally,the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product,restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in DHH protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. DHH plays a role both male gonadal differentiation and perineurial development.
DHH plays a role in intercellular signaling which is essential for a variety of patterning events during development. DHH functions as a spermatocyte survival factor in the testes & is essential for testes development.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人沙漠刺猬因子(DHH)产品为过滤灭菌的无色溶液;其中人沙漠刺猬因子(DHH)产品溶解于20mM MES pH 5.5,0.5mM DTT,20%甘油溶液中.