Periostin is a disulfide linked 90 kDa,811 amino acid protein originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment,attachment and spreading. Additionally,periostin expression has previously been shown to be significantly increased by both transforming growth factor beta-1(TGFbeta1) and bone morphogenetic protein (BMP-2). OSF-2 has a typical signal sequence,followed by a cysteine-rich domain,a fourfold repeated domain and a C-terminal domain. The fourfold repeated domain of OSF-2 shows homology with the insect protein fasciclin
Periostin mRNA is expressed in the developing mouse embryonic and fetal heart,and that it is localized to the endocardial cushions that ultimately divide the primitive heart tube into a four-chambered heart.
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大肠杆菌中重组表达
溶解建议
提供的人成骨细胞特异性因子2(Periostin)产品为过滤灭菌的冻干粉末;该冻干粉末是从含0.5 mg/ml人成骨细胞特异性因子2(Periostin)的0.05M醋酸盐缓冲液(pH 4)中过滤灭菌并冻干产生的.我们建议加0.2 ml 0.1M 醋酸盐缓冲液(pH 4)使粉末完全溶解.如要使pH值更大,我们建议通过相关缓冲液进一步稀释到10ug/ml.过高的浓度会影响Periostin的溶解性.