Pleiotrophin (Osteoblast-Specific Factor-1,OSF-1) contains 136 amino acid residues. The sequence is very rich in cationic amino acids (24% of the residues); lysine cluster sequences are found in the N-terminal and C-terminal ends of the structure.
The OSF-1 gene was shown by Northern blotting analysis to be expressed in mouse calvarial osteoblast-enriched cells and in mouse brain tissues,but not in thymus,spleen,kidney,liver,lung,testis or heart. Pleiotrophin has the ability to promote adhesion,migration,expansion,and differentiation of human osteoprogenitor cells. In addition to certain types of cancer,the embryonic growth and differentiation factor pleiotrophin is found also in adults in inflammatory diseases. In osteoarthritis,pleiotrophin is especially expressed in early stages,and its concentrations in the synovial fluid could serve as a marker for the progress of the disease. Pleitrophin might be involved in cartilage repair in osteoarthritis,in particular,in earlier stages.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人多效生长因子(Pleiotrophin)产品为过滤灭菌的冻干粉末;该冻干粉末是从含0.5 mg/ml人多效生长因子(Pleiotrophin)的0.1M磷酸盐缓冲液,0.1M NaCl,pH 7.2中过滤灭菌并冻干产生的.我们建议加0.2 ml PBS(pH 7.2)使粉末完全溶解.