Midkine (MK) is the product of a retinoic acid responsive gene,MK,and is a member of a family of heparin binding factors. It contains 121 amino acid residues including 10 conserved cysteine residues,all of which appear to be disulphide linked.
Midkine is expressed during embryogenesis,showing an expression pattern that suggests functions in neurogenesis,cell migration,secondary organogenetic induction,and mesoderm-epithelial interaction.
The widespread downregulation of MK in the adult human is reverted in a number of cancers,in which polypeptides are able to act as both transforming growth factors and promoters of angiogenesis.
Midkine (MK),induces chemotaxis of human neutrophils and was found to trigger mobilization of intracellular calcium of these cells.
Midkine induces histamine release from rat peritoneal mast cells with a rapid response in a dose dependent manner.
Midkine is also a potent stimulator of collagen and glycosaminoglycan synthesis.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人中期因子(Midkine)产品为冻干粉末;该冻干粉末是从含0.5mg/ml人中期因子(Midkine)的0.05M磷酸盐缓冲液和0.1M NaCl,pH 7.2中冻干产生的.我们建议加0.2 ml PBS pH 7.2使粉末完全溶解.