VU591 hydrochloride is a potent and selective blocker of renal outer medullary potassium channel, ROMK (Kir1.1). Kir1.1 channel is a putative drug target for a novel class of loop diuretic drugs that hold the ability to lower pressure and blood volume without causing hypokalemia. VU591 seems to block the intracellular pore of the channel and does so with an IC50 of 300 nM.
产品描述
A Blocker of Kir1.1 Channel
产品形式
VU591 hydrochloride is a potent and selective blocker of renal outer medullary potassium channel, ROMK (Kir1.1). Kir1.1 channel is a putative drug target for a novel class of loop diuretic drugs that hold the ability to lower pressure and blood volume without causing hypokalemia. VU591 seems to block the intracellular pore of the channel and does so with an IC50 of 300 nM.