Verapamil HCl is a phenylalkylamine that acts as a L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension. Verapamil is also effective in treating arrythmias2. Verapamil block of L-type channels is dependent on the membrane potential. The IC50 values at a holding potential of -80 or -40 mV are 250 and 15.5 µM, respectively. In Xenopus oocytes, Verapamil inhibits L-type currents in an activity dependent manner.
产品描述
A Potent Phenylalkylamine Blocker of L-type Ca2+ Channels
产品形式
L-type (CaV1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.
