Capsiate is a natural agonist of TRPA1 and TRPV1 channels with an effective concentration of 1-100 μM and an EC50 of 3 μM when binding to TRPA1. Capsiate is produced by a non-pungent cultivar of red pepper called Capsicum annuum L and is hypothesized to enhance energy metabolism by activating the sympathetic system and suppressing inflammation.
产品描述
A TRPA1 and TRPV1 Channel Activator
产品形式
Transient receptor potential vanilloid channels (TRPV) are members of TRP Channels. Members of this family are involved in many sensory processes such as pain, temperature and hearing1. Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channe, which is expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA1.
