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中文名称

CMPDA(25毫克)

英文名字
CMPDA
供应商
Alomone
产品货号
ALO-C-215-25
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
CMPDA is a new positive allosteric modulator of AMPA. Positive allosteric modulators of AMPA receptors act by enhancing normal AMPA receptor activity to mimic long-term potentiation and prolong open-channel time by slowing or preventing channel closure. Slowing the termination of a glutamate-evoked response enhances excitatory postsynaptic potentials by increasing ion flux through AMPA receptor channels1. CMPDA modulates AMPA subunit GluA2 receptor (GluR2) and its desensitization and deactivation (EC50 values are 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay of GluA2i and GluA2o receptors expressed in HEK293 Cell). This compound binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges2. This pocket is a powerful target for drug discovery of compounds that modulate AMPA receptors and is a possible site of action for endogenous metabolites
产品描述
An AMPA Receptor Positive Allosteric Modulator
产品形式
CMPDA is a new positive allosteric modulator of AMPA. Positive allosteric modulators of AMPA receptors act by enhancing normal AMPA receptor activity to mimic long-term potentiation and prolong open-channel time by slowing or preventing channel closure. Slowing the termination of a glutamate-evoked response enhances excitatory postsynaptic potentials by increasing ion flux through AMPA receptor channels1. CMPDA modulates AMPA subunit GluA2 receptor (GluR2) and its desensitization and deactivation (EC50 values are 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay of GluA2i and GluA2o receptors expressed in HEK293 Cell). This compound binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges2. This pocket is a powerful target for drug discovery of compounds that modulate AMPA receptors and is a possible site of action for endogenous metabolites
保存建议
艾美捷为您提供的Alonmone Labs原装进口的CMPDA (25 mg)产品可室温运输,建议您在收到产品后将其置于合适的温度下保存。
其他
Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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