The AMPAkine, 1-(quinoxalin-6-ylcarbonyl)-piperidine (CX516), is a brain-penetrating compound, which facilitates AMPA receptor-mediated transmission. CX516 has an EC50 in a hippocampal slice preparation of 150 μM as measured by patch clamp in cultured hippocampal neurons. The action of CX516 on AMPA receptor transmission results in memory enhancement, which has been demonstrated in rodents, primates, and humans.
产品描述
An Agonist of AMPA Receptors
产品形式
The AMPAkine families of drugs are positive allosteric modulators of AMPA receptors in the mammalian brain. These compounds facilitate learning and memory in both humans and animals. Positive modulation of AMPA receptors by AMPAkines can improve channel function by increasing receptor sensitivity to endogenous ligand and specific agonists.