- 中文名称
吡虫嗪(25毫克)
- 英文名字
- Cyclothiazide
- 供应商
- Alomone
- 产品货号
- ALO-C-205-25
- 产品报价
- ¥已停产
- 产品说明书
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- 产品新闻
- 背景资料
- Cyclothiazide (CTZ) is one of the most potent benzothiadiazides, a class of positive allosteric modulators of non-NMDA-type glutamate receptors that inhibit receptor desensitization with a marked selectivity for the flip splice variants of AMPA receptors. Specifically, CTZ is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. By using patch-clamp techniques, the effects of CTZ were studied in HEK 293 cells stably transfected with the rat flip GluR1 subunit. The AMPA currents were greatly potentiated by CTZ in a dose-dependent manner. For instance, pretreatment of the cells with 100 μM CTZ increased the peak AMPA currents by 90-fold (EC50 = 28 μM), the currents at the end of AMPA application by 636-fold (EC50 = 46 μM), and the current integrals by 730-fold (EC50 = 41 μM).
- 产品描述
- A Positive Allosteric Modulator of AMPA Receptors
- 产品形式
- Cyclothiazide (CTZ) is one of the most potent benzothiadiazides, a class of positive allosteric modulators of non-NMDA-type glutamate receptors that inhibit receptor desensitization with a marked selectivity for the flip splice variants of AMPA receptors. Specifically, CTZ is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. By using patch-clamp techniques, the effects of CTZ were studied in HEK 293 cells stably transfected with the rat flip GluR1 subunit. The AMPA currents were greatly potentiated by CTZ in a dose-dependent manner. For instance, pretreatment of the cells with 100 μM CTZ increased the peak AMPA currents by 90-fold (EC50 = 28 μM), the currents at the end of AMPA application by 636-fold (EC50 = 46 μM), and the current integrals by 730-fold (EC50 = 41 μM).
- 保存建议
- 艾美捷为您提供的Alonmone Labs原装进口的Cyclothiazide (25 mg)产品可室温运输,建议您在收到产品后将其置于合适的温度下保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
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