Chlorpromazine (CPZ) is a widely used PTZ. It has been reported that CPZ strongly affects the GABA-mediated inhibitory synaptic transmission by decreasing the amplitude and by accelerating the decay of miniature IPSCs (mIPSCs). A recent study showed that CPZ decreased the channel-opening frequency of nicotinic acetylcholine receptor (nAChR) and, thus, acted as a closed-channel blocker (IC50s values are ~10 µM).
产品描述
A Blocker of nAChRs and an Antagonist of Dopamine Receptors
产品形式
Phenothiazines (PTZs) are a family of compounds commonly used in the treatment of psychiatric disorders. The mechanism whereby these drugs exert their therapeutic effects appears to be through blockade of dopamine receptors. However, these substances have been shown to affect also a number of other physiologically important sites. PTZs also compete for serotonin and α-adrenergic and histamine receptors. Electrophysiological studies have shown that PTZs interfere with a number of ligand- and voltage-activated channels.