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中文名称

proBDNF(野生型小鼠)(0.25 mg)

英文名字
proBDNF (WT-mouse)
供应商
Alomone
产品货号
ALO-B-240-0.25
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
BDNF is a neurotrophic factor produced by proteolytic cleavage of its precursor, proBDNF. The biologically relevant form of the protein was thought to be the mature form, BDNF, which has been shown to affect the development of motoneurons, modulate synaptic transmission and affect axonal branching, dendrite growth and synapse number. These actions are mediated via the binding of BDNF to TrkB. Different actions are mediated by the binding of BDNF to p75 such as neuronal process retraction and neuronal apoptosis. The precursor form was thought to be important for the correct folding, secretion and trafficking of the mature protein. A single-nucleotide polymorphism (Val66 to Met) in the pro-domain of the human BDNF gene impairs intracellular trafficking and regulated secretion of BDNFnin primary cortical neurons and neurosecretory cells but not in endothelial and vascular cells. This has been shown to affect memory and lead to abnormal hippocampal function in humans.
产品描述
proBrain-Derived Neutrotrophic Factor (WT-mouse), Recombinant, E. coli
产品形式
BDNF is a neurotrophic factor produced by proteolytic cleavage of its precursor, proBDNF. The biologically relevant form of the protein was thought to be the mature form, BDNF, which has been shown to affect the development of motoneurons, modulate synaptic transmission and affect axonal branching, dendrite growth and synapse number. These actions are mediated via the binding of BDNF to TrkB. Different actions are mediated by the binding of BDNF to p75 such as neuronal process retraction and neuronal apoptosis. The precursor form was thought to be important for the correct folding, secretion and trafficking of the mature protein. A single-nucleotide polymorphism (Val66 to Met) in the pro-domain of the human BDNF gene impairs intracellular trafficking and regulated secretion of BDNFnin primary cortical neurons and neurosecretory cells but not in endothelial and vascular cells. This has been shown to affect memory and lead to abnormal hippocampal function in humans.
保存建议
艾美捷为您提供的Alonmone Labs原装进口的proBDNF (WT-mouse) (0.25 mg)产品可室温运输,建议您在收到产品后将其置于合适的温度下保存。
其他
Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
注意
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