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中文名称

GPER抗体(50 ul)

英文名字
Anti-GPER
供应商
Alomone
产品货号
ALO-AER-050-50
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
The G protein-coupled estrogen receptor (GPER), formerly known as G protein receptor 30 (GPR30), was identified as a novel estrogen receptor that mediates a rapid, non-genomic response to estrogens.nGPER is a G protein-coupled seven-transmembrane receptor. It is believed that the N-terminus is located outside of the cell, and that aspartic acid residues in the terminal region might be modified by glycosylation if GPER is localized in the plasma membrane. It is speculated that the ligand associates with the N-terminal domain to activate the receptor. Trimeric G protein is presumed to bind to the 3rd loop of the intracellular domain based on the molecular structure. A PDZ domain appears to be in the C-terminal region of GPER, but its physiological role is unknown.nGPER is widely distributed in the human body including: brain, liver, heart, lung, pancreas, placenta, blood vessels, bone, lymphoid tissue, as well as endometrial, ovarian and breast cancer. The receptor has been localized both in the plasma membrane and in the endoplasmic reticulum3.nIt was found that GPER is rapidly induced in the cardiomyocyte ischemia model, and that its induction is associated with apoptotic cell death during ischemia and reperfusion. In addition, the GPER mediates estrogenic signaling in breast cancer cells and cancer-associated fibroblasts (CAF) that contribute to cancer progression.
应用类型
经验证,该抗体可应用于WB等实验应用,也可用于IC、IFC、IH、IP等实验。
免疫原
GPER抗体的免疫原肽段为(C)ETFRDKLRLYVAQK。此免疫原序列来源于329-342 位氨基酸残基,该序列来源于大鼠GPER (Accession编号为O08878)。胞内, C端。
来源宿主
反应性
反应性:小鼠、 大鼠、也可反应于: 人
保存建议
艾美捷为您提供的GPER抗体(50 ul)为室温运输,建议您收到产品后﹣20℃保存。
其他
Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
注意
该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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