Urotensin II is a very powerful vasoconstrictive substance. The human Urotensin II receptor (UTIIR) was originally isolated as an orphan receptor (GPR14) in neural and sensory tissues.Urotensin II is expressed in various human tissues such as CNS, skeletal muscle, smooth muscle, pancreas, and heart. Binding of Urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that Urotensin II is also expressed in various kinds of tumor cells such as of adrenal tumors and neuroblastomas. In those cells Urotensin II was reported to stimulate cell growth.
应用类型
经验证,该抗体可应用于IH、WB等实验。
免疫原
Urotensin II 受体抗体的免疫原肽段为(C)RPLDTVQRSKGYRK。此免疫原序列来源于154-167 位氨基酸残基,该序列来源于大鼠UTIIR (Accession编号为P49684)。 第二胞内环。
来源宿主
兔
反应性
反应性:大鼠
保存建议
艾美捷为您提供的Urotensin II 受体抗体(50 ul)为室温运输,建议您收到产品后﹣20℃保存。