- 中文名称
线粒体钙单向调节剂1抗体（0.2 ml）
- 英文名字
- Anti-Mitochondrial Calcium Uniporter Regulator 1
- 供应商
- Alomone
- 产品货号
- ALO-ACC-321-0.2
- 产品报价
- ￥已停产
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- Ca2+ flux across the mitochondrial inner membrane regulates bioenergetics, cytoplasmic Ca2+ signals and activation of cell death pathways. Mitochondrial Ca2+ uptake occurs at regions of close apposition with intracellular Ca2+ release sites driven by the inner membrane voltage generated by oxidative phosphorylation and mediated by a Ca2+ selective ion channel called the uniporter. Mitochondrial calcium uniporter (MCU) was recently identified as an ion-conducting pore4. MCUR1 (mitochondrial calcium uniporter regulator 1), belongs to the CCDC90 family, an integral membrane protein required for MCU-dependent mitochondrial Ca2+ uptake. MCUR1 binds to MCU and regulates ruthenium-red-sensitive MCU-dependent Ca2+ uptake.nMCUR1 contains two transmembrane helices, where the N- and the short C-termini are exposed to the inter-membrane space.MCUR1 is ubiquitously expressed in mammalian tissues including: skeletal muscle, brain, heart, lung, liver, kidney, large intenstine and spleen.nIt was found that cells depleted of MCUR1 have abnormal bioenergetic properties similar to those observed in cells in which Ca2+ uptake is blocked. Thus, MCUR1 is necessary for MCU to efficiently promote mitochondrial Ca2+ uptake and to ensure normal mitochondrial bioenergetics.
- 应用类型
- 经验证，该抗体可应用于IH、WB等实验应用，也可用于 IC、IFC、IP、LCI等实验。
- 免疫原
- Mitochondrial Calcium Uniporter Regulator 1抗体的免疫原肽段为(C)GRNALGRLRLGARR。此免疫原序列来源于97-110 位氨基酸残基，该序列来源于小鼠 Mitochondrial Calcium Uniporter Regulator 1 (Accession编号为Q9CXD6)。胞内环。, mitochondrial matrix。
- 来源宿主
- 兔
- 反应性
- 反应性：小鼠、 大鼠
- 保存建议
- 艾美捷为您提供的Mitochondrial Calcium Uniporter Regulator 1抗体(0.2 ml)为室温运输，建议您收到产品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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