CaV1.1 (α1S) is the prototypical VGCCs. It was the first member of the CaV family to be cloned2. CaV1.1 is a single polypeptide composed of four relatively conserved repeats (I, II, II and IV) containing six α-helices a piece. The fourth α-helix of each repeat has a regularly spaced sequence of basic residues that is believed to be critical for voltage-sensing. The I–II-linker is the site of interaction with the intracellular β1a subunit .nCaV1.1 is expressed solely in skeletal muscle. It is localized in regions of the T-tubular membrane that are closely opposed to the sarcoplasmic reticulum (the TSR junction). The primary role of CaV1.1 is to serve as the voltage sensor for skeletal muscle-type excitation contraction (EC) coupling.nMutations in CaV1.1 have been identified as causative for two congenital muscle pathophysiologies: hypokalemic periodic paralysis5 (HypoKPP) and malignant hyperthermia.
应用类型
经验证，该抗体可应用于IH、WB等实验应用，也可用于 IC、IFC、IP、LCI等实验。
免疫原
CaV1.1 (胞外) antibody抗体的免疫原肽段为CGNVDPDESARIS。此免疫原序列来源于506-518 位氨基酸残基，该序列来源于大鼠CaV1。1 (Accession编号为Q02485)第二胞外环。, 结构域 IV
