- 中文名称
B1缓激肽受体抗体（50 ul）
- 英文名字
- Anti-B1 Bradykinin Receptor
- 供应商
- Alomone
- 产品货号
- ALO-ABR-011-50
- 产品报价
- ￥已停产
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868。
- 产品新闻
- 背景资料
- Kinins are small peptides rapidly produced following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) appear to initiate a similar cascade of events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function. Kinins such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and theB2 Bradykinin receptor (BKRB2). The desArg9-BK and Lys-desArg9-BK peptides activate BKRB1 while BK and Lys-BK operate by activating BKRB2. Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Expression of BKRB1is inducible upon various types of tissue injury and by inflammatory mediators such as bacterial lipopolysaccharide (LPS) and cytokines. BKRB1 was long considered not to be expressed in healthy tissues. However, recent work has demonstrated a low level of expression of BKRB1 in the CNS of rodent and primates. In contrast, BKRB2 is constitutively expressed on various cell types. BKRB1 represents a potential therapeutic target for treatment of inflammatory disorders and cardiovascular diseases.
- 应用类型
- 经验证，该抗体可应用于IH、WB等实验应用，也可用于IC、IFC、IP等实验。
- 免疫原
- B1 Bradykinin 受体抗体的免疫原肽段为(C)KEAS RTR*SG GPKGS K。此免疫原序列来源于243-257 位氨基酸残基，该序列来源于大鼠BKRB1 ，替代 cysteine 250 (C250) with serine (*S) (Accession编号为P97583)，第三胞内环。
- 来源宿主
- 兔
- 反应性
- 反应性：小鼠、 大鼠
- 保存建议
- 艾美捷为您提供的B1 Bradykinin 受体抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。
- 其他
- Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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