The angiotensin-(1-7) Mas receptor is the recently identified receptor of the biologically active heptapeptide angiotensin-(1-7).Angiotensin (Ang)-(1-7) is a metabolite of the well known peptide hormone Angiotensin (Ang) II, a key component of the renin-angiotensin system (RAS) that has a central role in cardiovascular homeostasis.n Considerably interest in Ang-(1-7) and its receptor aroused in the last few years since it became apparent that it can counterbalance most of Ang II effects. Thus Ang-(1-7) has vasodilator and hypotensive effects as well as antiarrhythmic and cardioprotective roles.The Ang-(1-7) Mas receptor belongs to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and was originally described as a protooncogene.Signaling via the Ang-(1-7) Mas receptor is still poorly elucidated however, evidence indicates that the receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC).The Ang-(1-7) Mas receptor is expressed in several organs including heart, kidney, blood vessels, testis and brain. Studies with Ang-(1-7) Mas receptor knockout mice have demonstrated the key role of this receptor in cardiovascular regulation as well as in the regulation of learning and memory.
应用类型
经验证,该抗体可应用于IH、WB等实验应用,也可用于 IC、IFC、IP等实验。
免疫原
Angiotensin-(1-7) Mas 受体抗体的免疫原肽段为(C)KIRKNTWASHSSK。此免疫原序列来源于212-224 位氨基酸残基,该序列来源于大鼠Angiotensin-(1-7) Mas 受体 (Accession编号为P12526),第三胞内环。
来源宿主
兔
反应性
反应性:人、 小鼠、 大鼠
保存建议
艾美捷为您提供的Angiotensin-(1-7) Mas 受体抗体(0.2 ml)为室温运输,建议您收到产品后﹣20℃保存。