Angiotensin II receptor type 2 or AT2 is one of the receptors that bind the octapeptide hormone Angiotensin II (Ang II).Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
应用类型
经验证,该抗体可应用于IC、IH、LCI等实验。
免疫原
Angiotensin II 受体 Type-2 (胞外)抗体的免疫原肽段为DNLNATGTNESAFNC。此免疫原序列来源于21-35 位氨基酸残基,该序列来源于大鼠AT2 受体 (Accession编号为P35351)。胞外, N端。
来源宿主
兔
反应性
反应性:小鼠、 大鼠
保存建议
艾美捷为您提供的Angiotensin II 受体 Type-2 (胞外)抗体(0.2 ml)为室温运输,建议您收到产品后﹣20℃保存。