英文名字 17-AAG
中文名称 17-AAG (0.1 mg)
供应商 Alomone
产品货号 ALO-A-580-0.1
产品报价 ¥1728/0.1mg
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产品新闻
背景资料 17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function. Hsp90 regulates the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. 17-AAG induces apoptosis and displays anti-tumor effects in tumor cells. 17-AAG depletes cancer cells of erbB-1, erbB-2, Raf-1, and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways.It also downregulates vascular endothelial growth factor (VEGF) expression. 17AAG is currently in phase I clinical trial in several centers worldwide. Preliminary data obtained from these trials demonstrate that anti tumor activity is achieved at concentrations below the maximum tolerated dose.
产品描述 An Anticancer Antibiotic
产品形式 17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function. Hsp90 regulates the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. 17-AAG induces apoptosis and displays anti-tumor effects in tumor cells. 17-AAG depletes cancer cells of erbB-1, erbB-2, Raf-1, and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways.It also downregulates vascular endothelial growth factor (VEGF) expression. 17AAG is currently in phase I clinical trial in several centers worldwide. Preliminary data obtained from these trials demonstrate that anti tumor activity is achieved at concentrations below the maximum tolerated dose.
产品说明书
其他 Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

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