AP-18 is a reversible TRPA1 blocker with an IC50 value of 3.1 and 4.5 μM for human and rat TRPA1 channels respectively.
产品描述
A Reversible TRPA1 Channel Blocker
产品形式
he transient receptor potential channel, also known as TRP, is one of the largest families of cation channels. TRPA1 is expressed in sensory and nociceptive neurons and has a significant role in inflammatory response. Bradykinin and Histamine receptors induce TRPA1 activity and in a study conducted on mice it was found that TRPA1 deficient mice did not develop an elevated mechanical and thermal pain response following Bradykinin injection. This suggests that TRPA1 has a vital role in Bradykinin signaling pathways.n TRPA1 also plays a role in acute and chronic respiratory disease pathophysiology. Prolonged exposure to TRPA1 agonists such as chlorine and aldehydes can cause reactive airways dysfunction syndrome characterized by symptoms such as wheezing, cough and dyspnea. In view of this TRPA1 may be a target in airway anti-inflammatory research.