HSPB3 encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal dominant distal hereditary motor neuropathy type 2C. HSPB3 (Heat Shock Protein Family B (Small) Member 3) is a Protein Coding gene. Diseases associated with HSPB3 include Neuronopathy, Distal Hereditary Motor, Type Iic and Distal Hereditary Motor Neuropathy, Type Ii. An important paralog of this gene is HSPB2-C11orf52.