GPR183 was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. GPR183 is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of GPR183 is unknown.