CENPO (Centromere Protein O) encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. CENPO is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prometaphase.