The protein encoded byTFAP2A is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in TFAP2A are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for TFAP2Ae.