ALS2 (ALS2, Alsin Rho Guanine Nucleotide Exchange Factor) is a Protein Coding gene. Diseases associated with ALS2 include Primary Lateral Sclerosis, Juvenile and Spastic Paralysis, Infantile Onset Ascending. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Vesicle-mediated transport.