The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. ALKBH3 (AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase) is a Protein Coding gene. Diseases associated with ALKBH3 include Prostate Cancer. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair.