The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP4 encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. AKAP4 (A-Kinase Anchoring Protein 4) is a Protein Coding gene. Diseases associated with AKAP4 include Retinitis Pigmentosa 70. Among its related pathways are Activation of cAMP-Dependent PKA and DAG and IP3 signaling.