SCG5 (Secretogranin V) is a Protein Coding gene. Diseases associated with SCG5 include Hereditary Mixed Polyposis Syndrome 1 and Hereditary Mixed Polyposis Syndrome. SCG5 encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2. Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function.