JunB is a basic region, leucine zipper (bZIP) transcription factor belonging to the Jun family that includes c-Jun and JunD. Jun family members homodimerize or heterodimerize with Fos and ATF proteins to form a functional transcription factor AP-1 (activator protein 1), whose activity is regulated by a variety of physiological and pathological stimuli such as growth factors, infections, and stress signals . While JunB sometimes antagonizes c-Jun transcriptional activity, it may functionally substitute for c-Jun during development in mice . JunB regulates hematopoietic stem cell number and plays an important role in the pathogenesis of chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) .蛋白别名为:JUNB; Transcription factor jun-B;基因ID为:3726;蛋白质ID:P17275
应用类型
IHC-p,IP,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: IHC-p: 1:100-1:300. IP: 2-5 ug/mg lysate. ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽:human Jun B around the phosphorylation site of S79.