HMGB1 encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. High mobility group box 1 plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of HMGB1 have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.蛋白别名为:HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1;基因ID为:3146;蛋白质ID:P09429
应用类型
WB,IHC-p,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-300 ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽:the N-terminal region of human HMG-1 around the acetylation site of K12.