CDKN1C is imprinted, with preferential expression of the maternal allele. Cyclin dependent kinase inhibitor 1C is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that CDKN1C is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for CDKN1C.蛋白别名为:CDKN1C; KIP2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2;基因ID为:1028;蛋白质ID:P49918
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽:human p57 around the acetylation site of K278.