Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK8 is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. Kallikrein related peptidase 8 may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of KLK8 results in multiple transcript variants encoding different isoforms.蛋白别名为:KLK8; NRPN; PRSS19; TADG14; Kallikrein-8; hK8; Neuropsin; NP; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein;基因ID为:11202;蛋白质ID:O60259
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽:the N-terminal region of human KLK8. at AA rangle: 30-110