DES(desmin) encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in DES are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.蛋白别名为:DES; Desmin;基因ID为:1674;蛋白质ID:P17661