X-ray repair cross complementing 4 encoded by XRCC4 functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. X-ray repair cross complementing 4 plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in XRCC4 can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. 蛋白别名为:XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4;基因ID为:7518;蛋白质ID:Q13426