- 中文名称
Connexin-43抗体
- 英文名字
- Connexin-43 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1320
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family form homomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels1,2. Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications1. For example, Connexin-43 (Cx43) protein level is regulated by its turnover rate and by phosphorylation of various residues which ultimately determines its activity rate1.
Gap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells3. They play important roles in different biological processes. These include differentiation, cell cycle synchronization, cellular development, neuronal activity and the immune response2,4,5.
Due to their important roles, mutations in connexins are linked with a number of diseases such as neurodegenerative disorders, skin diseases, deafness, and developmental abnormalities2,5,6.
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of human Connexin-43. Anti-Connexin-43 antibody (#AG1320) can be used in western blot analysis, immunohistochemistry and immunocytochemistry applications and was designed to recognize Connexin-43 from human, rat and mouse samples.
- 应用类型
- WB
- 免疫原
- P17302
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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