- 中文名称
【CYP2C9】(生物活性)人源细胞色素P450 2C9
- 英文名字
- EZCyp™ Active Human Cytochrome P450 2C9
- 供应商
- Biovision
- 产品货号
- 7875-50
- 产品报价
- ¥已停产
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- Cytochrome P450 2C9 (CYP2C9, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. In the liver, this enzyme contributes to the wide pharmacokinetic variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. CYP2C9 gene is highly polymorphic. More than 50 single nucleotide polymorphisms (SNPs) have been described in the regulatory and coding regions of the CYP2C9 gene, some of which are associated with reduced enzyme activity compared with wild type in vitro. Extrahepatic CYP2C9 often metabolizes endogenous compounds such as arachidonic acid, 5-hydroxytryptamine, and linoleic acid. BioVision’s EZCypTM 2C9 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2C9 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.
- 序列
- (生物活性)人源细胞色素P450 2C9又称Cytochrome P450 2C, Cytochrome P450 2C9, Cyt2C9, CYPIIC, CYPIIC9, Cyp2c, Microsomal cytochrome P450 2C9, active CYP2C9, human cyp2c9, human CYP2C9, recombinant CYP2C, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9.其对应NCBI基因号为1559,对应Accession号为P11712 .
- 来源宿主
- 提供的【CYP2C9】(生物活性)人源细胞色素P450 2C9蛋白产品来源为毕赤酵母中重组表达.
- 溶解建议
- 提供的(生物活性)人源细胞色素P450 2C9产品为固体冻干粉形式.溶解于25 mM磷酸钾缓冲液中, pH 7.7
- 保存建议
- 艾美捷推荐冰袋运输【CYP2C9】(生物活性)人源细胞色素P450 2C9产品.我们建议您收到该产品后将其置于-20°C保存.产品有效期为收到产品后12个月.
- 其他
- BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的Leader,BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理,艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.
- 注意
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该页面的中文产品信息的翻译,仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前,请浏览说明书确认。
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