中文名称

【IGF1】人源细胞表达重组人胰岛素样生长因子1

英文名字

Human CellExp™ IGF-1, human recombinant

供应商

Biovision

产品货号

7507-100

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Insulin-like growth factor 1 (IGF-1) also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 binds to at least two cell surface receptors: the Insulin-like growth factor 1 receptor, abbreviated as "IGF1R", and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6).

序列

人源细胞表达重组人胰岛素样生长因子1又称IGF-I, IGF1A, somatomedin C, MGF .其对应NCBI基因号为3479，对应Accession号为P05019.

来源宿主

提供的【IGF1】人源细胞表达重组人胰岛素样生长因子1蛋白产品来源为人胚肾HEK 293细胞中重组表达.

溶解建议

提供的人源细胞表达重组人胰岛素样生长因子1产品为固体冻干粉形式.开盖前，请先离心.溶解于PBS缓冲液中, pH 7.4. 请勿涡旋！

保存建议

艾美捷推荐冰袋运输【IGF1】人源细胞表达重组人胰岛素样生长因子1产品.我们建议您收到该产品后将其置于-20°C保存.产品有效期为收到产品后12个月.

其他

BioVision的公司总部在美丽的旧金山湾地区，它是全球生命科学公司的Leader，BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品，以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理，艾美捷与BioVision一起为研究者们提供优质、新的细胞生物学研究工具而不断扩大产品及服务质量.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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