Sphingosine-1-phosphate （S1P） is the product of phosphorylation of sphingosine by sphingosine kinase. Like many products of sphingomyelin， it exhibits a wide range of biological activities. Not only does it enhance cell growth， but it can inhibit the normal apoptotic response to a variety of stimuli. The ability of PKC to block apoptosis is likely due to the formation of S1P. S1P stimulates MAPK and counteracts the ceramide-induced activation of SAPK and JNK. It also increases intracellular calcium levels by both the liberation of calcium from internal stores and through activation of a Gi protein-coupled receptor resulting in the opening of a cell surface calcium channel.
产品描述
A potent lipid signaling molecule that exhibits a wide range of biological activities； it enhances cell growth and inhibits the normal apoptotic response to a variety of stimuli
