Heat shock proteins （HSPs） are ubiquitously expressed in all organisms. A major function of HSP90 and other HSPs is to act as molecular chaperones. HSP90 forms a complex with glucocorticoid receptor （GR），rendering the non-ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP56 or cyclophilin-40，forming an aporeceptor complex. HSP90 also exists as a dimer with other proteins such as p60/sti1 and p23，forming an aporeceptor complex with estrogen and androgen receptors.
应用类型
The antibody can be used in Western blotting （0.5-4 ug/ml）. Based on researchers feed back， the antibody also works well in immunoprecipitation （10-20 ug/ml） and immunohistochemistry （frozen sections， 10-20 ug/ml）. However， the optimal concentrations should be determined individually.
